High - intensity training reduces intermittent hypoxia - induced ER stress and 1 myocardial infarct size
نویسندگان
چکیده
3 4 Guillaume Bourdier, Patrice Flore, Hervé Sanchez, Jean-Louis Pepin, Elise Belaidi 5 and Claire Arnaud 6 7 Grenoble Alpes University, HP2 laboratory, Grenoble, F-38042 France 8 INSERM, U1042, Grenoble, F-38042 France 9 IRBA, Operational Environments, Brétigny/Orge, F-91223 France 10 *co-senior authors 11 12 13 14 Corresponding author at: 15 Laboratoire HP2, Institut Jean Roget, Facultés de Médecine-Pharmacie de Grenoble, BP 170, 16 38042 Grenoble Cedex 9, France. 17 Tel: +33 476 63 7556 18 Fax: +33 476 63 7178 19 E-mail address: [email protected] 20 21 Source of financial support: Fond de dotation « Agir pour les maladies chroniques » 22 23 Running title: High-intensity training and intermittent hypoxia 24 25 Word count of body (without abstract, references and legends): 4557 26 27 Articles in PresS. Am J Physiol Heart Circ Physiol (November 13, 2015). doi:10.1152/ajpheart.00448.2015
منابع مشابه
High-intensity training reduces intermittent hypoxia-induced ER stress and myocardial infarct size.
Chronic intermittent hypoxia (IH) is described as the major detrimental factor leading to cardiovascular morbimortality in obstructive sleep apnea (OSA) patients. OSA patients exhibit increased infarct size after a myocardial event, and previous animal studies have shown that chronic IH could be the main mechanism. Endoplasmic reticulum (ER) stress plays a major role in the pathophysiology of c...
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